Breakthrough is the CIM’s voice. It goes to donors, patients, and friends of the CIM around the world. Breakthrough also goes to doctors, scientists and administrators at Johns Hopkins and at the other academic medical centers. Those audiences aren’t always the same. We have a lot of interesting stuff going on here, and the trick is to convey what’s happening in a tone that will not cause a lay audience to glaze over, even if the story is about very basic science, or the activities of policy wonks, or the nature of academic medicine. At the same time, we aim to tell our stories in such a way that scientists, clinicians, and academicians won’t feel they’re being talked down to – not always an easy balance. But we think we manage to pull it off, and the key is that we’re excited about what’s happening here. We hope you will be excited about it too!